Description
- SKU:
- 10-3204-10mg
- Additional Names:
- 1-Ethylbenzimidazolinone
- CAS Number:
- 10045-45-1
- Extra Details:
- A direct activator of small-conductance Ca2+-activated K+ channels (SK) which dose-dependently relaxes rat mesenteric vessels.1 Reverses ischemia-induced cognitive impairment2 and displays neuroprotective effects in ischemia-induced neuronal cell death3. Induces embryonic stem cell differentiation into cardiomyocytes and enrichment of pacemaker-like cells.4 Induces production of superoxide and hydrogen peroxide in neutrophils with subsequent apoptosis.5
- Molecular Weight:
- 162.19
- Physical State:
- Crystalline solid
- References:
- 1) Adeagbo et al. (1999), 1-Ethyl-2-benzimidazolinone stimulates endothelial K(Ca) channels and nitric oxide formation in rat mesenteric vessels; Eur. J. Pharmacol., 379 151 2) Orfila et al. (2014), Increasing small conductance Ca2+-activated potassium channel activity reverses ischemia-induced impairment of long-term potentiation; Eur. J. Neurosci., 40 3179 3) Allen et al. (2011), SK2 channels are neuroprotective for ischemia-induced neuronal cell death; J. Cereb. Blood Flow Metab., 31 2302 4) Muller et al. (2012), Ca2+ activated K channels-new tools to induce cardiac commitment from pluripotent stem cells in mice and men; Stem Cell Rev., 8 720 5) Fay et al. (2006), SK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes; Proc. Natl. Acad. Sci. USA, 103 17548
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Room Temperature
- Supplier:
- Focus Biomolecules
- Purity:
- 98% by HPLC NMr (Conforms)
- Chemical Name:
- 1-Ethyl-1,3-dihydro-2H-benzimidazol-2-one