Description
- SKU:
- GJ-030
- Additional Names:
- Panx-1 mimetic inhibitory peptide, 10Panx1
- CAS Number:
- 955091-53-9
- Extra Details:
- 10Panx mimics a sequence (WRQAAFVDSY) in the second extracellular loop of Panx1 and is a panx-1 mimetic inhibitory peptide that blocks pannexin 1 gap junctions. 10Panx can inhibit Panx1 hemichannel mediated ATP release and inflammasome activation in astrocytes and macrophages and in vivo, pharmacological blockade of Panx1 hemichannels with 10Panx peptide attenuates the progression of acetaminophen induced hepatotoxicity, neuropathic pain and epilepsy
- Molecular Weight:
- 1242.37
- Purity:
- >95% by hplc
- References:
Wang et al (2007) Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters. Am.J.Physiol.Cell Physiol. 293 C1112 PMID: 17652431
Bravo et al (2014) Pannexin 1: a novel participant in neuropathic pain signaling in the rat spinal cord. Pain 155(10) 2108 PMID: 25102401
Chen (2019) Enhanced Macrophage Pannexin 1 Expression and Hemichannel Activation Exacerbates Lethal Experimental Sepsis. Sci Rep. 9(1) 160 PMID: 30655582
- Sequence:
- H-Trp-Arg-Gln-Ala-Ala-Phe-Val-Asp-Ser-Tyr-OH
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store dry, frozen and in the dark
- Supplier:
- Isca Biochemicals
- Formula:
- C58H79N15O16
- Solubility:
- Soluble to 1 mg/ml in water