Description
- SKU:
- 10-1601-5mg
- CAS Number:
- Not found
- Extra Details:
- Semi-synthetic analog of geldanamycin which possesses an acetylenic side chain for coupling to other probes, fluorophores and bioactive molecules such as steroids via click chemistry.1 Chemical modifications at C17 are well known not to interfere with binding of geldanamycin to HSP90 client proteins.2-4
- Molecular Weight:
- 538.67
- Physical State:
- Violet solid
- References:
- 1) Hendricks et al. (2013), Synthesis and preliminary evaluation steroidal anti-estrogen-geldanamycin conjugates; Bioorg. Med. Chem. Lett., 23 3635 2) Llauger-Bufi et al. (2003), Synthesis of novel fluorescent probes for the molecular chaperone Hsp90; Bioorg. Med. Chem. Lett., 13 3975 3) Kim et al. (2004), Development of a fluorescence polarization assay for the molecular chaperone Hsp90; J. Biomol. Screen., 9 375 4) Austin et al. (2012), Fragment screening using capillary electrophoresis (CEfrag) for hit identification of heat shock protein 90 ATPase inhibitors; J. Biomol. Screen, 17 868
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20°C
- Supplier:
- Focus Biomolecules
- Purity:
- 98% by TLC, NMR (Conforms)
- Chemical Name:
- 17-(Propargylamino)-17-desmethoxygeldanamycin
