Description
- SKU:
- 10-3238-5mg
- CAS Number:
- 1133387-90-2
- Extra Details:
- Inhibits glutathione reductase and thioredoxin reductase,IC50s=6.7 and 8.7 µM respectively, and impairs mitochondrial function.1 May be used to induce a cellular model of thiol oxidative stress.2 Enhances sensitivity of cancer cell lines to X-ray irradiation.3 Induces G2/M cell cycle arrest by inducing thiol oxidative stress resulting in ?-tubulin S-glutathionylation-mediated microtubule depolymerization.4 Improves limb revascularization by glutathionylation and subsequent stabilization of HIF-1?.5
- Molecular Weight:
- 518.65
- Physical State:
- White or off-white solid
- References:
- 1) de Souza et al. (2017), Inhibition of reductase systems by 2-AAPA modulates peroxiredoxin oxidation and mitochondrial function in A172 glioblastoma cells Toxicol. In Vitro, 42 273 2) Xie et al. (2014), Evaluation of a dithiocarbamate derivative as a model of thiol oxidate stress in H9c2 rat cardiomyocytes; Free Radic. Biol. Med. 70 214 3) Zhao et al. (2009), Increase in thiol oxidative stress by glutathione reductase inhibition as a novel approach to enhance cancer sensitivity to X-ray irradiation ; Free Radic. Biol. Med., 47 176 4) Li et al. (2017), 2-acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylcarbonylamino)phenylcarbamoylsulfanyl] propionic acid, a glutathione reductase inhibitior, induces G2/M cell cycles arrest through generation of thiol oxidative stress in human esophageal cancer cells; Oncotarget, 8 61846 5) Watanabe et al. (2016), Glutathione adducts induced by ischemia and deletion of glutatedoxin-1 stabilize HIF-1? and improve limb revascularization; Proc. Natl. Acad. Sci. USA, 113 6011
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20°C
- Supplier:
- Focus Biomolecules
- Purity:
- 98% by HPLC
- Chemical Name:
- R,R?-2-Acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylthiocarbonylamino)-phenylthiocarbamoylsulfanyl]propionic acid, hydrate