Description
- SKU:
- 10-2685-20mg
- Additional Names:
- FCDR, FdCyd, NSC-48006, Ro 5-1090
- CAS Number:
- 10356-76-0
- Extra Details:
- A DNA methyltransferase inhibitor currently in clinical trials for breast cancer and other solid tumors1. Like 5-Azacytidine and decitabine, 2-Deoxy-5-fluorocytidine is a pyrimidine analog that integrates into chromatin to inhibit DNA methylation2. It blocks proliferation in colon cancer-derived HCT116 cells by activating DNA response pathways3. It inhibits various strains of pathogenic avian influenza viruses in vitro and in vivo4.
- Molecular Weight:
- 245.21
- Physical State:
- White solid
- References:
- 1) Ren et al. (2011), DNA hypermethylation as a chemotherapy target; Cell Signal, 23 1082 2) Gowher et al. (2004), Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy; Cancer Biol. Ther., 3 1062 3) Zhao et al. (2002), Inhibition of cancer cell proliferation by 5-fluoro-2-deoxycytidine, a DNA methylation inhibitor, through activation of DNA damage response pathway; Springerplus, 1 65 4) Kumaki et al. (2001), In vitro and in vivo efficacy of fluorodeoxycytidine analogs against highly pathogenic avian influenza H5N1, seasonal, and pandemic H1N1 virus infections; Antiviral Res., 92 329
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20°C
- Supplier:
- Focus Biomolecules
- Purity:
- 98% by TLC, NMR (Conforms)
- Chemical Name:
- 5-fluoro-2deoxycytidine
