Description
- SKU:
- 10-4536-1mg
- CAS Number:
- 20380-11-4
- Extra Details:
- Metabolite resulting from the action of sterol 27-hydroxylase on cholesterol. Concentrations of 27-hydroxycholesterol are elevated in patients with Alzheimers disease and mild cognitive impairment.1,2 Endogenous selective estrogen receptor modulator3 and ligand for the liver X receptor(EC50 = 85nM for LXR? and 71nM for LXR?)4.
- Molecular Weight:
- 402.66
- Physical State:
- White solid
- References:
- 1) Heverin et al. (2004), Changes in the levels of cerebral and extracerebral sterols in the brains of patients with AlzheimerÂ’s disease; J.Lipid Res. 45 186 2) Shafaati et al. (2011), Marked accumulation of 27-hydroxycholesterol in the brains of AlzheimerÂ’s patients with the Swedish APP 670-671 mutation; J.Lipid Res. 52 1004 3) Umetani et al. (2007), 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen; Nature Medicine, 13 1185 4) Fu et al. (2001), 27-Hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells; J.Biol.Chem. 276 38378
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20°C
- Supplier:
- Focus Biomolecules
- Purity:
- 98% by HPLC, NMR (Conforms)
- Chemical Name:
- 27-Hydroxycholesterol; 5,25R-Cholesten-3?,26-diol
