Description
- SKU:
- B-0341-2
- Additional Names:
- 2206-20-4, 3ac, inhibitor, ship, ship1
- Extra Details:
- SH2-Domain containing inositol 5-phosphatases (SHIP1 & SHIP2) dephosphorylate the 5-position of PI(3,4,5)P3 generating PI(3,4)P2. SHIP2 is ubiquitously expressed while SHIP1 is only found in hematopoietic lineage cells. 3AC is a selective inhibitor of SHIP1 (EC50 = 10 ?M) and shows no inhibition of the other isoform, SHIP2, at concentrations up to 1 mM. 3AC promotes apoptosis of SHIP1-expressing leukemia cells (KG-1) and multiple myeloma cells (OPM) suggesting SHIP1 inhibition is a potential drug target for blood cancers. Mice treated with 3AC show increased numbers of MIR cells in the spleen and lymph nodes and increased numbers of granulocytes.
Storage
4°CFeatured in References
1) R. Brooks, et al., "SHIP1 Inhibition Increases Immunoregulatory Capacity and Triggers Apoptosis of Hematopoietic Cancer Cells" J. Immun., 2010, 184, 3582-3589. 2) M. Fuhler, et al. "Therapeutic Potential of SH2 Domain-Containing Inositol-5-Phosphatase 1 (SHIP1) and SHIP2 Inhibition in Cancer" Mol. Med, 2012, 18, 65-75. 3) Drobek, A., J. Kralova, et al. (2015). "PSTPIP2, a Protein Associated with Autoinflammatory Disease, Interacts with Inhibitory Enzymes SHIP1 and Csk." The Journal of Immunology. DOI:10.4049/jimmunol.1401494 4) Akyol, G. Y., et al. (2017). "IVIG activates FcgRIIB-SHIP1-PIP3 Pathway to stabilize mast cells and suppress inflammation after ICH in mice." Scientific Reports 7(1): 15583. 5) Rasmussen, P., et al. (2019). "Inhibiting phosphatase SHIP-1 enhances suboptimal IgE-mediated activation of human blood basophils but inhibits IgE-mediated activation of cultured human mast cells." Immunology Letters 210: 40-46.
Documents
Technical Data Sheet - Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Echelon Biosciences
