Description
- SKU:
- 10-1307-1g
- CAS Number:
- 491-36-1
- Extra Details:
- Inhibitor of poly(ADP-ribose) polymerase (PARP) (IC50 = 9.5 ?M)1. Displays mixed inhibition with respect to NAD+. Protective against ischemia-reperfusion induced ROS production, and subsequent mitochondrial and cell damage in rat heart2. Anti-inflammatory in LPS-induced endotoxic mice in vivo; decreases NF-?B and AP-1 activation3.
- Molecular Weight:
- 146.15
- Physical State:
- White or off-white solid
- References:
- 1) Banasil et al. (1992), Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase; J. Biol. Chem., 267 1569 2) Halmosi et al. (2001), Effect of poly(ADP-ribose_ polymerase inhibitors on the ischemia-reperfusion-induced oxidative cell damage and mitochondrial metabolism in Langendorff heart perfusion system. Clin. Mol. Pharmacol., 59 1497 3) Veres et al. (2004), Regulation of kinase czscades and transcription factors by a poly(ADP-ribose) polymerase-1 inhibitor, 4-hydroxyquinazoline, in lipopolysaccharide-induced inflammation in mice; J. Pharmacol. Exp. Ther., 310 247
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20°C
- Supplier:
- Focus Biomolecules
- Purity:
- 98% by HPLC NMR (Conforms)
- Chemical Name:
- 4-(1H)-Quinazolinone