Description
- SKU:
- 10-1276-250mg
- Additional Names:
- 5-FU
- CAS Number:
- 51-21-8
- Extra Details:
- 5-Fluorouracil (5-FU) is a clinically useful anticancer agent that acts via irreversible inhibition of thymidylate synthase. The active metabolites of 5-FU are 5-Fluorodeoxyuridylate (5-FdUMP), 5-Fluorodeoxyuridine triphosphate (5-FdUTP) and 5-Fluorouridine triphosphate (5-FUTP). The primary cytotoxic effect of 5-FU is believed to be inhibition of thymidylate synthase by 5-FdUMP. Secondary effects include incorporation of 5-FdUTP into DNA resulting in DNA strand breaks and incorporation of 5-FUTP into RNA causing abnormal RNA processing.1
- Molecular Weight:
- 130.08
- Physical State:
- White solid
- References:
- 1) Schlisky (1998), Biochemical and Clinical Pharmacology of 5-Fluorouracil; Oncology 12 13
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20°C
- Supplier:
- Focus Biomolecules
- Purity:
- 98%
- Chemical Name:
- 5-Fluoro-1H,3H-pyrimidine-2,4-dione