Description
- SKU:
- 10-4538-5mg
- CAS Number:
- 566-26-7
- Extra Details:
- Metabolite resulting from the action of cholesterol 7 alpha-hydroxylase on cholesterol. 7?-Hydroxycholesterol is the first intermediate and a rate-limiting step in the major pathway for bile acid synthesis in humans. A pro-inflammatory mediator which upregulates production of CCL2 and MMP9 in macrophages and may promote progression of atherosclerosis.2,3 Possible biomarker for cellular lipid peroxidation.4
- Molecular Weight:
- 402.66
- Physical State:
- White or pale yellow solid
- References:
- 1) Duane and Javitt (2002), Conversion of 7 alpha-hydroxycholesterol to bile acid in human subjects: is there an alternate pathway favoring cholic acid synthesis?; J. Lab. Clin. Med., 139 109 2) Kim et al. (2015) 7?-Hydroxycholesterol induces inflammation by enhancing production of chemokine (C-C motif) ligand 2; Biochem. Biophys. Res. Commun., 467 879 3) Kim et al. (2014) 27-Hydroxycholesterol and 7alpha-hydroxycholesterol trigger a sequence of events leading to migration of CCR5-expressing Th1 lymphocytes; Toxicol. Appl. Pharmacol., 274 462 4) Saito and Noguchi (2014) 7-Hydroxycholesterol as a possible biomarker of cellular lipid peroxidation: difference between cellular and plasma lipid peroxidation; Biochem. Biophys. Res. Commun., 446 741
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20°C
- Supplier:
- Focus Biomolecules
- Purity:
- 98% by TLC [3:2 ethyl acetate : hexane; Rf = 0.15] NMR (Conforms)
- Chemical Name:
- 5-Cholesten-3?, 7?-diol