Description
- SKU:
- 10-1436-5mg
- Additional Names:
- Teriflunomide
- CAS Number:
- 108605-62-5
- Extra Details:
- A pyrimidine biosynthesis inhibitor and immunomodulator.1 Inhibits the mitochondrial dihydroorotate dehydrogenase (DHODH).2 Leflunomide is rapidly metabolized in human hepatocytes to A77 1726.3 Cell permeable.
- Molecular Weight:
- 270.21
- Physical State:
- White solid
- References:
- 1) Manna et al. (1999), Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-kappa B activation and gene expression; J. Immunol., 162 2095 2) Davis et al. (1996), The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase; Biochemistry, 35 1270 3) Seah et al. (2008), Oxidative bioactivation and toxicity of leflunomide in immortalized human hepatocytes and kinetics of the non-enzymatic conversion to its major metabolite, A77 1726; Drug Metab. Lett., 2 153
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20°C
- Supplier:
- Focus Biomolecules
- Purity:
- 98% by TLC, NMR (conforms)
- Chemical Name:
- 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide