AA43279

SKU:

10-3503-25mg

CAS Number:

354812-16-1

Extra Details:

Selective Nav1.1activator. In HEK-293 cells expressing human Nav1.1 channels AA43279 increased the Nav1.1-mediated current in a concentration dependent manner (EC50=9.5 µM). In rat hippocampal brain slices it increased the firing activity parvalbumin-expressing, fast-spiking GABAergic interneurons and increased the spontaneous inhibitory post-synaptic currents recorded from pyramidal neurons. It displayed anticonvulsant activity in vivo. Important tool compound for exploring the physiology of Nav1.1 channels.1

Molecular Weight:

248.30

Physical State:

Tan solid

References:

1) Frederiksen et al. (2017), A small molecule activator of Nav 1.1 channels increases fast-spiking interneuron excitability and GABAergic transmission in vitro and has anti-convulsive effects in vivo.; Eur. J. Neuroscience, 46 1887

Shipping Conditions:

Ambient

Storage Conditions:

-20°C

Supplier:

Focus Biomolecules

• Manufacturer's Data Sheet:

Purity:

97% by TLC NMr (Conforms)

Chemical Name:

3-Amino-5-(4-methoxyphenyl)thiophene-2-carboxamide