Description
- SKU:
- PP-120
- Additional Names:
- DPPA-1
- CAS Number:
- 1620813-53-7
- Extra Details:
- (D)-PPA 1 is a programmed death protein 1/ programmed death-ligand 1 (PD-1/PD-L1) interaction inhibitor. (D)-PPA 1 binds to PD-L1 with a Kd of 0.51 ?M and can inhibit interaction at a concentration of 1 mg/mL in flow cytometry experiments. (D)-PPA 1 is a hydrolysis-resistant D-peptide and can disrupt the PD-1/PD-L1 interaction in vivo, inhibiting tumour growth and prolonging survival time in mouse models.
- Molecular Weight:
- 1555.67
- Purity:
- >95% by hplc
- References:
Chang et al (2015) Blocking of the PD-1/PD-L1 interaction by a D-peptide antagonist for cancer immunotherapy. Angew Chem.Int.Ed.Engl. 54 11760 PMID: 26259671
Sun et al (2018) PD-1/PD-L1 pathway and angiogenesis dual recognizable nanoparticles for enhancing chemotherapy of malignant cancer. Drug Deliv. 25(1) 1746 PMID: 30394118
- Sequence:
- H-(D)-Asn-(D)-Tyr-(D)-Ser-(D)-Lys-(D)-Pro-(D)-Thr-(D)-Asp-(D)-Arg-(D)-Gln-(D)-Tyr-(D)-His-(D)-Phe-OH
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store dry, frozen and in the dark
- Supplier:
- Isca Biochemicals
- Formula:
- C70H98N20O21
- Solubility:
- Soluble to 2 mg/ml in water
