Description
- SKU:
- 10-3017-1g
- Additional Names:
- o-Phenanthroline hydrochloride hydrate
- CAS Number:
- 18851-33-7
- Extra Details:
- 1,10-phenanthroline is a high affinity chelator of divalent metal ions and may be used to inhibit zinc metalloenzymes.1 It is a potent inhibitor of JAMM-type isopeptidases (DUBs) acting via chelation of an active site Zn2+. It may be used when preparing cell lysates for enrichment of ubiquitinated proteins which are especially sensitive to DUBs in the JAMM family.2,3
- Molecular Weight:
- 234.68
- Physical State:
- White solid
- References:
- 1) Swann et al (1981) Zinc metalloenzyme properties of active and latent collagenase from rabbit bone. Biochem.J. 195 41 2) Cooper et al. (2009) K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1 EMBO J. 28 621 3) Lu et al. (2015) Substrate degradation by the proteasome: A single-molecule kinetic analysis Science 348 200
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Room Temperature
- Supplier:
- Focus Biomolecules
- Purity:
- 98% by TLC NMR (Conforms)
