Description
- SKU:
- 10-2956-10mg
- CAS Number:
- 331830-20-7
- Extra Details:
- Potent inhibitor of prolyl 4-hydroxylase (IC50=2-4 ?M)1. Inhibits collagen deposition via inhibition of collagen proline hydroxylation2,3. Subcutaneous injection of a 1,4-DPCA containing hydrogel into Swiss Webster mice that do not show a regenerative phenotype increased expression of HIF1? over 5 days. Multiple injections led to regenerative wound healing after ear hole punch injury4.
- Molecular Weight:
- 240.22
- Physical State:
- Off-white solid
- References:
- 1) Franklin et al. (2001), Inhibition of prolyl 4-hydroxylase in vitro and in vivo by members of a novel series of phenanthrolinones; Biochem. J., 353 333 2) Xiong et al. (2014), Prolyl-4-hydroxylase ? subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition; BMC Cancer, 14 1 3) Love and Jones et al. (2013), Transient inhibition of connective tissue infiltration and collagen deposition into porous poly(lactic-co-glycolic acid) discs; J. Biomed. Mater. Res., 101 3599 4) Zhang et al. (2015), Drug induced regeneration in adult mice; Sci. Transl. Med., 7 290ra92
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Room Temperature
- Supplier:
- Focus Biomolecules
- Purity:
- 98% by HPLC, NMR (Conforms)
- Chemical Name:
- 1,4-Dihydrophenonthrolin-4-one-3-carboxylic acid
