1400W

SKU:

10-4501-25mg

CAS Number:

214358-33-5

Extra Details:

Potent, tight-binding, slow inhibitor of inducible nitric oxide synthase (iNOS). Highly selective for iNOS3 (Ki = 7 nM) over nNOS or eNOS (Ki’s of 2 µM and 50 µM respectively).1 Cell permeable and active in vivo.2

Molecular Weight:

250.17

Physical State:

White solid

References:

1) Garvey et al. (1997), 1400W is a slow, tight-binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo; J. Biol. Chem., 272 4959 2) Thomsen et al. (1997), Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: Studies with 1400W, a novel inhibitor; Cancer Res., 57 3300 3) Pigott et al. (2013), On the selectivity of neuronal NOS inhibitors; Br. J. Pharmacol., 168 1255

Shipping Conditions:

Ambient

Storage Conditions:

-20°C

Supplier:

Focus Biomolecules

• Manufacturer's Data Sheet:

Purity:

98% by TLC [Pyridine/HOAc/H2O/n-Butanol 1:2:2:6; Rf = 0.30] NMR (conforms)

Chemical Name:

N-(3-Aminomethyl)benzyl)acetamidine dihydrochloride