Description
- SKU:
- 10-1282-1g
- Additional Names:
- 6-TG, NSC 752, NSC 76504
- CAS Number:
- 154-42-7
- Extra Details:
- After incorporation into DNA, it disrupts cytosine methylation by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo.1 It reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNA methyltransferase (DNMT1).2 Incorporates into DNA and induces double strand breaks which destabilize DNA structure resulting in cytotoxicity.3 Selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance in a xenograft model.4 Anticancer and immunosuppressive activity.
- Molecular Weight:
- 167.19
- Physical State:
- Pale yellow solid
- References:
- 1) Wang and Wang (2009), 6-thioguanine perturbs cytosine methylation at the CpG dinucleotide site by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo; Biochemistry, 48 2290 2) Yuan et al. (2011), 6-thioguanine reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNMT1; Cancer Res., 71 1904 3) Bohon and de los Santos (2005), Effect of 6-thioguanine on the stability of duplex DNA; Nucleic Acid Res., 33 2880 4) Issaeva et al. (2010), 6-thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance; Cancer Res., 70 6268
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20°C
- Supplier:
- Focus Biomolecules
- Purity:
- 96% by HPLC NMr (Conforms)
- Chemical Name:
- 2-Amino-6-mercaptopurine