Description
- SKU:
- 10-1327-5mg
- CAS Number:
- 909910-43-6
- Extra Details:
- Potent and selective ALK4, 5 and 7 inhibitor1,2. IC50=45, 12 and 7.5 nM respectively. Prevents phosphorylation of Smad2/3 and growth inhibition induced by TGF?2. Inhibits differentiation of rat induced pluripotent stem cells and increases clonal expansion efficiency3. Together with AMI-5, A83-01 enabled Oct4-induced reprogramming of mouse embryonic fibroblasts4. Cell permeable. Active in vivo.
- Molecular Weight:
- 421.53
- Physical State:
- Light yellow solid
- References:
- 1) Vogt. et al. (2011), The specificities of small molecule inhibitors of the TGF? and BMP pathways; Cell Signal., 23 1831 / 2) Tojo et al. (2012), Characteristic differences among osteogenic cell populations of rat bone marrow stromal cells isolated from untreated, hemolyzed or Ficoll-treated marrow; Cancer Sci., 96 791 / 3) Li et al. (2009), Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors; Cell Stem Cell, 4 16 / Yuan et al. (2011), Brief report: combined chemical treatment enables Oct4-induced reprogramming from mouse embryonic fibroblasts; Stem Cells, 29 549
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20°C
- Supplier:
- Focus Biomolecules
- Purity:
- 98% by TLC, NMR (Conforms)
- Chemical Name:
- 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
