Anti Cartilage Oligomeric Matrix Protein (COMP) mAb (Clone 2127F5)

COMP - Cartilage oligomeric matrix protein - belongs to the thrombospondin family of ECM components and is a prominent multidomain glycoprotein of cartilage, accounting for up to 1% of the wet weight of articular tissues and having an approximate Mr of 97 kDa [1-4]. COMP may also be found in tendon, bone (i.e. osteoblasts), ligament, certain smooth muscles and synovium and more recently has been discovered to be a primary constituent of the dermal ECM [5]. In the ECM COMP is present in a pentameric, disulfide-bonded complex of about 550 kDa, often seen associated with the chondrocyte cell surface [3, 5].

References:
1) Oldberg A, et al. (1992) J Biol Chem. 267(31):22346-50. PMID: 1429587
2) Hedbom E, et al. (1992) J Biol Chem. 267(9):6132-6. PMID: 1556121
3) Morgelin M, et al. (1992) J Biol Chem. 267(9):6137-41. PMID: 1556122
4) Cesare PE, et al. (1995) J Orthop Res. 13(3):422-8. PMID: 7602403
5) Agarwal P, et al. (2012) J Biol Chem. 287(27):22549-59. PMID: 22573329