Anti CD81 Antigen (TAPA-1/Tspan-28) mAb (Clone 12C4, TF5 Labeled)

CD81 (TAPA-1) is a cell surface protein which belongs to the tetraspanin superfamily. CD81 is identified as a component of the B lymphocyte receptor (BCR) and as a receptor for the Hepatitis C Virus. Importantly, it is found on the surface of exosomes.

Exosomes are cell-derived vesicles bounded by a lipid bilayer membrane and exhibiting a diameter of 50 to 150 nm. They are secreted from cultured cells and are observed in body fluids such as saliva, blood, urine, amniotic fluid, malignant ascites. Recent studies indicate that exosomes contain various proteins and RNAs, suggesting a role in information transfer between cells.

This monoclonal antibody can be used to immunoprecipitate exosomes from serum and culture supernatants.

References:
1) Takahashi A et al., Nat Commun. 2017 May 16;8:15287. doi: 10.1038/ncomms15287.
2) M Somiya et al., J Extracell Vesicles. 2018 Feb 21;7(1):1440132. doi:10.1080/20013078.2018.1440132. eCollection 2018.