Anti Chondroitin Sulfate A (Chondroitin-4-Sulfate) mAb (Clone 2H6)

Chondroitin sulfate, a polysaccharide moiety of proteoglycans, is one of the major components of the extracellular matrix. It is composed of the repeating unit, [→4GlcA 1→3GalNAc 1→], commonly sulfated at C-4 and/or C-6 of GalNAc. In the central nervous system, the most abundant glycosaminoglycan is chondroitin sulfate rich in [GlcA-GalNAc(4S)], namely chondroitin sulfate A. Chondroitin sulfate polysaccharides are involved in the formation, regeneration, and maintenance of the neural network. This monoclonal antibody effectively recognizes chondroitin sulfate A, especially in glycosaminoglycans occurring in the developing central nervous system.

References:
1) Oohira, A., et al. (1994) Neuroscience. 60:145-157. PMID: 8052408.
2) Yamamoto, Y., et al. (1995) Eur. J. Histochem. 39:265-272. PMID: 8835180.