Anti DEP Domain-Containing Protein 1B (XTP1/XTP8) mAb (Clone 2191H11)

The RhoGAP family embraces a unique member named XTP1 (also referred to as DEPDC1B, BRCC3 or FLJ11252) and pairing with a homologue denoted SDP35 (also referred to as DEPDC1, DEP8, FLJ20354 or DEPDC1-V2). The structural-functional properties of XTP1 are still largely unknown, but its structural uniqueness resides in the presence of a domain showing homology with Dishwelled, i.e. the DEP domain (Dishwelled/Pleckstrin-like domain). The presence of this domain suggests that XTP1 might engage in more complex molecular interactions than those of other members of the family. Another peculiar feature of XTP1 is represented by its atypical GAP domain, which lacks the orthodox “Arg finger” catalytic motif essential for exerting canonical GAP function. Whereas most RhoGAP family members are either ubiquitously expressed throughout the body or are concentrated in discrete tissue/organs, XTP1 is remarkably poorly represented in most human adult tissues (also supported by evidence provided by the Comparative Cancer Genome Project database). XTP1 is de novo expressed upon neoplastic transformation and remains abundant in many cancer cell lines. Some observations in epithelial tumors suggest that it may act as a cell-cycle regulator.