Anti DNA-Directed RNA Polymerase II Subunit RPB1 (POLR2A) CTD Phosopho-Ser5 mAb (Clone 1H4B6)

RNA polymerase II (RNAPII) transcribes all protein-coding genes and many non-coding genes, and the activity of RNAPII correlates with the phosphorylation state of RPB1, the large catalytic subunit of RNAPII.. RPB1 has an unusual C-terminal domain (CTD) that consists of repeats of the heptapeptide consensus sequence N-Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7-C, of which there are 52 copies in mammals. The amino acids in these repeats are potential targets for modification, such as phosphorylation and glycosylation.

References:
1) Odawara et al. (2011) BMC Genomics. 12:516. PMID: 22011111.