Description
Application: WB, IF, ICC
Clonality: Monoclonal
Host: Mouse
Purification: Ion-exchange Chromatography
Reactivity: Human
DNA polymerase eta ( 713 aa, 78 kDa) is specifically involved in DNA repair. Plays an important
role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA
synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the
context, it inserts the correct base, but causes frequent base transitions and transversions. May play a role in
hypermutation at immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites,
but does not have lyase activity. Targets POLI (Pol iota) to replication foci.
Immunogen: Human recombinant full-size Pol eta tagged with His6.
Applications: Western blot. Not tested for other application
Reactivity: Human Pol eta protein. Not tested in other species
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Clonality: Monoclonal
Host: Mouse
Purification: Ion-exchange Chromatography
Reactivity: Human
DNA polymerase eta ( 713 aa, 78 kDa) is specifically involved in DNA repair. Plays an important
role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA
synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the
context, it inserts the correct base, but causes frequent base transitions and transversions. May play a role in
hypermutation at immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites,
but does not have lyase activity. Targets POLI (Pol iota) to replication foci.
Immunogen: Human recombinant full-size Pol eta tagged with His6.
Applications: Western blot. Not tested for other application
Reactivity: Human Pol eta protein. Not tested in other species
