Description
Clonality: Polyclonal
Host: Rabbit
Purification: Serum
Reactivity: Drosophila
FACT (Facilitates Chromatin Transcription) is a protein complex involved in chromatin remodeling and comprises two subunits, SSRP1 and SPT16. A recent Drosophila study suggested that FACT forms a complex with a DNA binding protein, GAGA factor, to regulate sequence-specific changes in chromatin structure. SSRP1 and SPT16 have come to be noted as important new factors linking FACT and GAGA factors.
dSSRP1 is the Drosophila ortholog of SSRP1. Studies have revealed that dSSRP1 facilitates various chromatin transactions such as transcriptional regulation, DNA replication and histone replacement. This antibody against dSSRP1 is a powerful tool for Western blots (Ref.1), immunostaining (Ref.2), immunoprecipitation and chromatin immunopreciptation (Ref.1,2,3).
Source: Dr. Susumu Hirose, National Institute of Genetics
References:
1) Shimojima, T. et al. , (2003) Genes & Dev . 17, 1605-1616.
2) Saunders, A. et al. , (2003) Science , 301, 1094-1096.
3) Nakayama, T. et al. , (2007) Genes & Dev . 21, 552-561.
