Description
Application: ICC, IF, WB
Clonality: Monoclonal
Host: Mouse
Purification: IgG
Reactivity: S. cerevisiae, Human, S. pombe, Tetrahymena
Nucleoporin 98 (Nup98) is a component of nuclear pore complex (NPC), which is a large protein
assembly embedded in the nuclear envelope and highly conserved in eukaryotes. It is localized on
both nuclear and cytoplasmic side of NPC.
This protein contains glycine-leucine-phenylalanine-glycine (GLFG) amino acid repeats and
plays a critical role in nuclear trafficking. Nup98 also plays a specific role in the RNA export. In
addition, Nup98 plays roles in several important biological events such as gene expression, mitotic
checkpoint, and pathogenesis
Nup98 gene is fused to a variety of partner genes in human myeloid and T-cell malignancies via
chromosomal translocation.
In ciliates, a unicellular organism havingtwo functionally distinct nuclei, GLFG-Nup98 is present
in one of the nuclei and a distinct Nup98 ortholog is present in the other nucleus, and these
different Nup98s participate in a nucleus-selective transport mechanism. Application: 1) Most suitable for Western blotting, (Human, S. cerevisiae, S. pombe, Tetrahymena. Not tested in
other species)
2) Immunofluorescence staining / Immunocytochemistry for S. cerevisiae, S. pombe and
T.etrahymena. Not suitable for IF in human
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Clonality: Monoclonal
Host: Mouse
Purification: IgG
Reactivity: S. cerevisiae, Human, S. pombe, Tetrahymena
Nucleoporin 98 (Nup98) is a component of nuclear pore complex (NPC), which is a large protein
assembly embedded in the nuclear envelope and highly conserved in eukaryotes. It is localized on
both nuclear and cytoplasmic side of NPC.
This protein contains glycine-leucine-phenylalanine-glycine (GLFG) amino acid repeats and
plays a critical role in nuclear trafficking. Nup98 also plays a specific role in the RNA export. In
addition, Nup98 plays roles in several important biological events such as gene expression, mitotic
checkpoint, and pathogenesis
Nup98 gene is fused to a variety of partner genes in human myeloid and T-cell malignancies via
chromosomal translocation.
In ciliates, a unicellular organism havingtwo functionally distinct nuclei, GLFG-Nup98 is present
in one of the nuclei and a distinct Nup98 ortholog is present in the other nucleus, and these
different Nup98s participate in a nucleus-selective transport mechanism. Application: 1) Most suitable for Western blotting, (Human, S. cerevisiae, S. pombe, Tetrahymena. Not tested in
other species)
2) Immunofluorescence staining / Immunocytochemistry for S. cerevisiae, S. pombe and
T.etrahymena. Not suitable for IF in human
