Description
Clonality: Monoclonal
Host: Rat
Purification: IgG
Reactivity: Mouse, Human
Nucleoporin p62 (p62) is a protein complex associated with the nuclear envelope. The p62 protein remains associated with the nuclear pore complex-lamina fraction. p62 is synthesized as a soluble cytoplasmic precursor of 61 kDa[5] followed by modification that involve addition of N-acetylglucosamine residues,[6] followed by association with other complex proteins.
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform.[7]
P62 appears to interact with mRNA during transport out of the nucleus.[13] P62 also interacts with a nuclear transport factor (NTF2) protein that is involved in trafficking proteins between cytoplasm and nucleus.[14] Another protein, importin (beta) binds to the helical rod section of p62, which also binds NTF2 suggesting the formation of a higher order gating complex.[15] Karyopherin beta2 (transportin), a riboprotein transporter also interacts with p62.[16] P62 also interacts with Nup93,[17] and when Nup98 is depleted p62 fails to assemble with nuclear pore complexes.[18] Mutant pores could not dock/transport proteins with nuclear localization signals or M9 import signals. [from: Wikipedia contributors. (2019, February 16). Nucleoporin 62. In Wikipedia, The Free Encyclopedia. Retrieved 22:34, June 4, 2019, from https://en.wikipedia.org/w/index.php?title=Nucleoporin_62&oldid=883556059]
References:
1) Fukuhara et al. (2006) Hybridoma. 25:51-59.
2) Maeshima et al. (2006) J. Cell Sci. 119:4442-4451.
This antibody is used in refs 1 and 2.
