Anti Probable ATP-Dependent RNA Helicase DDX58 (RIG-I/RLR-1) mAb (Clone SS1A)

RIG-I like receptors (RLRs) are a family of DExD/H box RNA helicases that function as cytoplasmic sensors of pathogen-associated molecular patterns (PAMPs) within viral RNA (reviewed in (Onoguchi, Yoneyama et al. 2011)). The RLRs signal downstream transcription factor activation to drive type 1 interferon (IFN) production and antiviral gene expression that elicits an intracellular immune response to control virus infection. To date, three RLR members have been identified: RIG-I (retinoic acid-inducible gene I) – the founding member and therefore best characterized of this family, MDA5 (melanoma differentiation associated factor 5), and LGP2 (laboratory of genetics and physiology 2 and a homolog of mouse D11lgp2). Anti-RIG-I antibody is a rat monoclonal antibody obtained from immunization with a 16 amino acid peptide from the C-terminus of mouse RIG-I. This antibody can be used for the detection of mouse RIG-I by immunoblotting.