Description
Application: ELISA, WB, Neutralization
Clonality: Monoclonal
Host: Mouse
Purification: IgG
Reactivity: Clostridium tetani
Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the
axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2. Application: 1. Western blotting (1/1,000 dilution)
2. ELISA (assaydependent)
3. Neutralising of the toxin activity (assay dependent)
Other applications have not been tested.
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Clonality: Monoclonal
Host: Mouse
Purification: IgG
Reactivity: Clostridium tetani
Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the
axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2. Application: 1. Western blotting (1/1,000 dilution)
2. ELISA (assaydependent)
3. Neutralising of the toxin activity (assay dependent)
Other applications have not been tested.
