Description
Reactivity: Rat
This EIA kit is used for quantitative determination of rat.. glicentin in plasma sample. The kit is characterized for sensitive quantification, high specificity and no influence with other components in plasma and needlessness of sample pre-treatment. Glicentin standard used in the kit is a highly purified synthetic product... Supplementary: Competitive
Applicable Sample: Plasma
Other: Glicentin is a 69-amino-acid peptide containing glucagon and oxyntomodulin sequences in the molecule. It is suggested that glicentin and oxyntomodulin are produced in the intestinalL-cells and glucagon in A-cells in the pancreas, these peptides are derived from a common precursor by two different tissue-specific processing pathways. In 1983, the amino acid sequence of human glicentin was deduced by Bell et al. from the genomicsequence of human preproglucagon. Glicentin is a major form of gut glucagon-like immunoreactants (Gut GLIs).
In mammalian small intestine, proglucagon is processed into glicentin, oxyntomodulin, and glucagon like peptide 1(GLP-1) and glucagon-like peptide 2 (GLP-2). GLP-1(7-37) and GLP-1(7-36)amide have been isolated from the intestine and pancreas. It has been known that the GLP-1 sequence is well conserved between species in all mammals studied. Using synthetic peptides, several investigators have demonstrated that in contrast to GLP-1 (1-37), truncated GLP-1(7-36)amide and GLP-1(7-37) have several physiological effects. However, the physiological role of glicentin, a major gut glucagon, is still unclear. It has been known that the circulating level of plasma glicentin-like peptides increases significantly nutrient ingestion.
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This EIA kit is used for quantitative determination of rat.. glicentin in plasma sample. The kit is characterized for sensitive quantification, high specificity and no influence with other components in plasma and needlessness of sample pre-treatment. Glicentin standard used in the kit is a highly purified synthetic product... Supplementary: Competitive
Applicable Sample: Plasma
Other: Glicentin is a 69-amino-acid peptide containing glucagon and oxyntomodulin sequences in the molecule. It is suggested that glicentin and oxyntomodulin are produced in the intestinalL-cells and glucagon in A-cells in the pancreas, these peptides are derived from a common precursor by two different tissue-specific processing pathways. In 1983, the amino acid sequence of human glicentin was deduced by Bell et al. from the genomicsequence of human preproglucagon. Glicentin is a major form of gut glucagon-like immunoreactants (Gut GLIs).
In mammalian small intestine, proglucagon is processed into glicentin, oxyntomodulin, and glucagon like peptide 1(GLP-1) and glucagon-like peptide 2 (GLP-2). GLP-1(7-37) and GLP-1(7-36)amide have been isolated from the intestine and pancreas. It has been known that the GLP-1 sequence is well conserved between species in all mammals studied. Using synthetic peptides, several investigators have demonstrated that in contrast to GLP-1 (1-37), truncated GLP-1(7-36)amide and GLP-1(7-37) have several physiological effects. However, the physiological role of glicentin, a major gut glucagon, is still unclear. It has been known that the circulating level of plasma glicentin-like peptides increases significantly nutrient ingestion.
