Description
- SKU:
- 10-1097-1mg
- Additional Names:
- Tanespimycin
- CAS Number:
- 75747-14-7
- Extra Details:
- Semi-synthetic analog of geldanamycin which is less toxic and more stable. Selectively binds to and inhibits HSP90 from tumor cells. Anti-angiogenic activity. Cell permeable.
- Molecular Weight:
- 585.70
- Physical State:
- Purple or dark red solid
- References:
- 1) Schulte et al., (1998), The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin; Cancer Chemother. Pharmacol. 42 273 / 2) Kamal et al., (2003), A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors; Nature 425 407 / 3) Kaur et al., (2004), Therapeutic and diagnostic implications of Hsp90 activation; Clinical Cancer Res. 10 4813
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Room Temperature
- Supplier:
- Focus Biomolecules
- Purity:
- >98% by TLC NMR Conforms
- Chemical Name:
- 17-(Allylamino)-17-desmethoxygeldanamycin
