Description
- SKU:
- 10-4545-25mg
- CAS Number:
- 1250-95-9
- Extra Details:
- 5?,6?-Epoxycholesterol is a naturally occurring metabolite of cholesterol. It is a major oxysterol found in processed food1 and has been implicated in atherosclerosis2,3. 5?,6?-Epoxycholesterol has been found to be an endogenous ligand for LXR (EC50 = 76 nM).4
- Molecular Weight:
- 402.65
- Physical State:
- White solid
- References:
- 1) Leonarduzzi et al. (2002), Oxidized products of cholesterol: dietary and metabolic origin, and proatherosclerotic effect (review); J.Nutr.Biochem 13 700 2) Björkhem et al. (1988), Assay of unesterified cholesterol-5,6-epoxide in human serum by isotope dilution mass spectrometry. Levels in the healthy state and in hyperlipoproteinemia; J.Lipid Res. 29 1031 3) Staprans et al. (2005), The role of dietary oxidized cholesterol and oxidized fatty acids in the development of atherosclerosis; Mol.Nutr.Food Res. 49 1075 4) Berrodin et al. (2010), Identification of 5?,6?-Epoxycholesterol as a novel modulator of Liver X Receptor; Mol.Pharmacol. 78 1046
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20°C
- Supplier:
- Focus Biomolecules
- Purity:
- 98% by HPLC, NMR (Conforms)
- Chemical Name:
- Cholestan-5?,6?-epoxy-3?-ol
