Description
- SKU:
- 10-1066-10mg
- CAS Number:
- 944261-79-4
- Extra Details:
- Potent, selective inhibitor of the TTX-resistant voltage-gated sodium channel Nav1.8. Nav1.8 is preferentially expressed in sensory neurons, and inhibition attenuates both inflammatory and neuropathic pain in a variety of animal models. IC50's for rat and human Nav1.8 are 140 nM and 8.0 nM respectively.
- Molecular Weight:
- 357.80
- Physical State:
- white solid (MP = 128-130°C)
- References:
- 1) Jarvis et al. (2007), A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat; Proc. Natl. Acad. Sci. USA, 104 8520 / 2) McGaraughty et al. (2008), A selective Nav1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats; J. Pharmacol. Exp. Ther., 324 1204
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Room Temperature
- Supplier:
- Focus Biomolecules
- Purity:
- 98% by TLC [50% ethyl acetate in hexanes, Rf = 0.58] NMR Conforms
- Chemical Name:
- 5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide