Description
- SKU:
- IG-010
- Extra Details:
- A20FMDV2 is a peptide derived from the foot-and-mouth disease virus with a high affinity and selectivity for the alpha-v beta-6 (?v?6) arginyl-glycinyl-aspartic acid (RGD)-binding integrin, inhibiting alphavbeta6-ligand binding with a IC50 of 3 nmol/L, an activity 1,000-fold more selective for alphavbeta6 than for other RGD-directed integrins (alphavbeta3, alphavbeta5, and alpha5beta1).
- Molecular Weight:
- 2162.5
- Purity:
- >95% by HPLC
- References:
Hausner et al (2007) Use of a Peptide Derived from Foot-and-Mouth Disease Virus for the Noninvasive Imaging of Human Cancer: Generation and Evaluation of 4-[18F]Fluorobenzoyl A20FMDV2 for In vivo Imaging of Integrin ?v?6 Expression with Positron Emission Tomography. Cancer Res. 67(16) 7833 PMID: 17699789
Slack et al (2016) Pharmacological Characterization of the ?v?6 Integrin Binding and Internalization Kinetics of the Foot-and-Mouth Disease Virus Derived Peptide A20FMDV2. Pharmacology 97(3-4) 114 PMID: 26734728
- Sequence:
- H-Asn-Ala-Val-Pro-Asn-Leu-Arg-Gly-Asp-Leu-Gln-Val-Leu-Ala-Gln-Lys-Val-Ala-Arg-Thr-NH2
- Shipping Conditions:
- Ambient
- Storage Conditions:
- We recommend storage desiccated, frozen and in the dark
- Supplier:
- Isca Biochemicals
- Formula:
- C93H164N32O27
- Solubility:
- Soluble in water