Granulocyte-Colony Stimulating Factor (G-CSF) (rCSF3/900), CF640R conjugate, 0.1 mg/mL

Recombinant monoclonal antibody for detection of Granulocyte-Colony Stimulating Factor (G-CSF).

Product Information

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Description

This monoclonal antibody recognizes granulocyte-colony stimulating factor (G-CSF) in the cytoplasm of mature granulocytes. It shows no reactivity with any other cell types. Markers of myeloid cells are useful in the identification of different levels of cellular differentiation. It reacts with early precursor and mature forms of myeloid cells.

The antibody is useful for the detection of myeloid leukemias and granulocytic sarcomas and can be used as a marker of granulocytes in normal tissues or inflammatory processes. G-CSF is a pleiotropic cytokine that influences differentiation, proliferation and activation of the neutrophilic granulocyte lineage.

Human G-CSF cDNA encodes a 207 amino acid precursor containing a 29 amino acid signal peptide that is proteolytically cleaved to form a 178 amino acid mature protein. Two G-CSF forms, which are identical except for a three amino acid deletion in the amino-terminus of one form, have been isolated from human cells. Murine and human G-CSF share 73% sequence identity at the amino acid level.

Primary antibodies are available purified or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability.

Note: Conjugates of blue fluorescent dyes such as CF®405S and CF®405M are not recommended for detecting low-abundance targets because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Key Features

• CF640R: Fluorescent conjugate
• rCSF3/900: Recombinant monoclonal clone
• 0.1 mg/mL: Antibody concentration
• IHC: FFPE verified application

Antibody Specifications

Applications

This antibody is verified for immunohistochemistry using formalin-fixed, paraffin-embedded (FFPE) samples.

• IHC
• FFPE
• Detection of granulocyte-colony stimulating factor
• Identification of myeloid cell differentiation
• Detection of myeloid leukemias
• Detection of granulocytic sarcomas
• Identification of granulocytes in normal tissues and inflammatory processes

Positive Control: Tonsil or lymph node (IHC).

Formulation & Conjugate

Storage & Stability

Synonyms

Pluripoietin; Filgrastim; Lenograstim; CSF3OS; G-CSF; chromosome 17 open reading frame 33 (C17orf33); colony stimulating factor 3 (granulocyte)

Product Details

Granulocyte-Colony Stimulating Factor (G-CSF) CF640R Conjugate

Recombinant monoclonal antibody for G-CSF detection in immunohistochemistry and FFPE applications.

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.